7 Reasons Why You Should Not Mix Benadryl and Alcohol

You Should Not Mix Benadryl and Alcohol. Changing weather causes health issues like sneezing, runny nose, cough with itchy eyes, and headaches.

With a wide range of over-the-counter medicines, these seasonal allergies can be dealt with quickly. The best part is, most of these medications do not have any side effects.

But they can potentially cause some harm to your body if mixed with certain eatables or drinks. One of the popular cold remedies is Benadryl syrup. It is frequently used to treat various severe symptoms.

Diphenhydramine is the chemical name of Benadryl that interferes with the chemical compound called histamine in your body.

As histamine is responsible for responding to allergens in your body, you experience various symptoms of cold-like a blocked nose, itchy eyes, and other reactions when your body comes in contact with any of such allergen.

To get rid of these cold symptoms, buying Benadryl without a prescription is common. Do you know, Benadryl is a strong medication?

There are some risks that are associated with the careless use of Benadryl. One of the risky combinations is Benadryl and Alcohol, which affect your central nervous system adversely.

Why Should You Not Take Benadryl and Alcohol Together?

You Should Not Mix Benadryl and Alcohol

Both Benadryl and Alcohol act as Central Nervous System (CNS) depressants. CNS is made up of the spinal cord and brain. The combination of Alcohol and Benadryl slows down the nervous system to the extent that you start experiencing sedation and drowsiness.

Any task which needs physical or mental alertness becomes complicated to execute.

Misuse of Benadryl

Frequently Benadryl is misused as a sleep aid. As alcohol serves the same purpose, people experiencing insomnia may commit a mistake to combine them both to attain a peaceful sleep. But, do you know that this combination will hamper your sound sleep drastically?

You will start feeling Drizzy. Benadryl can adversely react with other medications and sleeping aids.

The sole purpose of Benadryl is to use it for treating allergies only.

1- In Senior

As Alcohol and Benadryl together make it difficult to control your body irrespective of your age, senior people are highly prone to it. Older adults are generally weak with specific visual impairments or some other health issues. When the dizziness of both alcohol and Benadryl starts working together, it mainly causes more harm to seniors.

2- Driving Warning

As your CNS goes very low, you should never take the risk of driving after consuming Benadryl and Alcohol together. As alcohol increases the effect of Benadryl, it can severely hamper the driver’s concentration.

We already know that drinking while driving or before driving is harmful, this harmful effect multiplies with taking Benadryl along.

3- Alcohol present in other medications

If you think that you are safe by not taking alcohol with Benadryl, you are wrong! There are many hidden sources of alcohol, like the presence of alcohol in certain medications up to 10%. If these drugs are consumed along with Benadryl, they are bound to react.

To avoid any such misuse, it is highly recommended to check labels showing the contents of the medications to ensure the absence of alcohol in a particular drug that can be consumed along with Benadryl. Medicines like sedatives, stomach ulcer medicines, antihistamines, antidepressants, diazepam, and other cold & cough medicines can interact with Benadryl.

4- Dehydration

Both alcohol and Benadryl are responsible for dehydrating the body. When mixed, they are bound to dehydrate the body at a higher rate and pose a risk. Besides excessive hangover, it causes extreme discomfort.

5- Memory impairment

As Benadryl is responsible for blocking the neurotransmitter, which is essential for memory and learning, alcohol, together with Benadryl, blocks these actions temporarily. The bizarre effect of alcohol is known for inhibiting memory and learning temporarily. Hence combining Benadryl and alcohol can have a severe impact on the mind.

6- Dementia

The risk of dementia increases with the constant use of anticholinergic drugs for up to 3 years. The same effect of alcohol can be observed. If you are consuming alcohol a Benadryl for an extended period, it leads to an increased risk of dementia.

7- Sex

Alcohol-related harm is more susceptible to females as their bodies contain lesser water for alcohol. Hence, the alcohol concentration is more in females than the males leading to more drowsiness and sedation in females. Thus, even consuming a smaller amount of alcohol with Benadryl has significant adverse interaction effects.


The risk of mixing alcohol and Benadryl is not necessarily applicable to everyone. However, it is highly recommended to refrain from mixing alcohol and Benadryl. If you are in a safe environment, you can consume small amounts of drink along with Benadryl.

But, if you need to indulge in some activity that requires any mental or physical alertness, it is highly recommended to avoid the consumption of alcohol with Benadryl. Consult your doctor before taking Benadryl and alcohol together to understand its implications on your body. Every human is different with a different resistance level.

Hence, a combination safe for someone might not be that safe for your body as well. Several factors, such as your age, medications, immunity, gender, etc. play a decisive role in determining the effects of alcohol and Benadryl together in your body.

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