Progesterone Side Effects [2021] Progesterone Can Be Bad For You?

“Hey wait a minute, what is progesterone anyway and how can it be bad for me?” This is the response most people, maybe even you, tend to give when asked the question, “Do you know what the progesterone side effects are?” 

Progesterone is a hormone that almost all women’s bodies produce. What Does Progesterone Do?

Therefore, it may be hard for most people, perhaps you, to believe that progesterone would have any side effects, but it does, and these side effects are mentioned below.

What is Progesterone?

What Does Progesterone Do?


Before discussing what the progesterone side effects are, it’s time to explain what progesterone is.  As mentioned earlier, progesterone is a hormone that the vast majority of women’s bodies make. It is a steroid hormone. Though the body naturally makes it, it can be made in a laboratory.

This synthetic progesterone is referred to as progestin. Progesterone and progestin are necessary for women to have regular and healthy periods and pregnancies.

And because female reproductive hormones regulate many vital body functions like blood pressure and heart rate, progestin is prescribed as part of hormone replacement therapy (HRT) for women who have completed menopause.  

More About HRT Progesterone

The type of progesterone that is used in hormone replacement therapy (HRT) is known as Prometrium. It is a progestin because it is human-made.

And as with all human-made drugs and medicines, it has side effects. The common side effects include:

Progesterone Effects

  • Dizziness
  • A sensation of the room and surroundings spinning
  • Abdominal pain – this comes in the form of severe cramping
  • Headaches – sometimes they can be of migraine quality
  • Tender and sore breasts or breast pain
  • Pain in the muscles supporting skeletal bones
  • Joint pain
  • Viral infections
  • Diarrhea
  • Nausea
  • Bloating
  • Constant tiredness (fatigue)
  • Hot flashes
  • Hair growth
  • Acne 
  • A constant cough
  • Dramatic and rapid weight gain or loss
  • Itching, dryness, and/or discharge from or in the vagina
  • Blurred vision
  • Drowsiness
  • Mood swings
  • Irritability

Some of the side effects are explained in greater detail below.  

Dizziness Caused By Promethium

Dizziness is caused by low blood pressure. When a woman’s blood pressure is shallow, her body is unable to pump enough blood and nutrients to her brain. 

This affects its short and long-term function because its neurons are not able to fire and function normally. In extreme cases, dizziness can lead to the woman passing out, though this is very rare. 

Though rare, Promethium has been known to dramatically lower blood pressure in some women who take it, especially if they make it with other medicines.

In these instances, the Promethium can negatively interact with these medicines.

Abdominal Pain as a Side Effect of Promethium

Though rare, Promethium can lead to abdominal pain or cramping, which can be severe in some cases. 

This type of pain is caused when organs in the abdomen become inflamed or stretched.  

Headaches Caused By Promethium

There are three main categories for defining headaches

  1. Primary headaches – 
  2. Secondary headaches
  3. Cranial neuralgia

Promethium can cause primary and secondary headaches. Primary headaches are migraine, tension, and cluster headaches. 

They include an entire range of minor headaches of various types. Of all of the primary headaches, women who take Promethium will experience, tension headaches will make up most of them. 

According to the latest studies done by the World Health Organization (WHO) about 5% of the general population (most of them women) suffer from tension headaches. 

Migraine headaches are the second most common type of primary headache.

Women tend to suffer more than men from these types of headaches. Cluster headaches are not experienced very often, and when they are, it is generally by men in their early 20’s.

Secondary headaches are caused by structural defects in the neck and face, or by infection.  

Because they are either caused by structural defects and/or infection, they can be caused by a variety of maladies ranging from pain resulting from infected teeth to diseases like encephalitis and meningitis, which can cause severe internal bleeding in the brain.

Headaches can have many causes. The most commonly suffered headache is the migraine headache

A woman gets a migraine headache when the muscles surrounding and supporting the brain become inflamed or irritated. 

The sufferer feels this pain in the neck, skull, and face but not in the brain because the brain has no pain receptors – therefore it is incapable of feeling and communicating pain.

The Relationship Between Prometrium And Breast Pain/Tenderness

Prometrium’s active and main ingredient is a female reproductive hormone. 

Female reproductive hormones can cause breast pain and tenderness especially if their levels in the woman’s body are too high or low. 

Numerous clinical studies done over the years have confirmed this. Many women experience slight breast pain and tenderness shortly before the start of their periods and during their periods.

Does Prometrium Cause Joint Pain?

The answer is, “yes Prometrium can cause joint pain!”  the main ingredient in Prometrium, progesterone can cause joints to become inflamed, especially if the levels in the sufferer are too high or low. 

Commonly affected joints include those in the back, knees, shoulders, and ankles.

You know you have joint pain if it hurts to move and the area around the affected joints are red, tender, swollen, warm, lock together when you move, don’t move properly when you walk or move, stiff, weak, or don’t move at all when you walk or run.

Progesterone Side Effects – FAQs 

What happens when you have too much progesterone?

When a woman is diagnosed with polycystic ovarian syndrome (PCOS) or women who have endometriosis and are taking progesterone tablets, they may be surprised to learn that the body does not make this hormone.

While it is correct that progesterone does help reduce the effect of these conditions on a woman’s body, there are many other factors that cause PCOS and other endometriosis symptoms to occur. As such, if you are currently taking progesterone tablets but find that your symptoms are not being controlled.

You should speak with your doctor before continuing your prescriptions. Although taking the wrong dosage can affect how well the tablet works in conjunction with other medications, if your doctor determines that you are not getting the proper amount of progesterone for your condition, there are other options available.

What are the benefits of taking progesterone?

What are the benefits of taking progesterone? The progesterone hormone acts as an anti-estrogen. This means that taking the hormone could potentially have positive effects on a woman’s reproductive organs, as estrogen is the primary female hormone that causes many of the problems with fertility in women.

What are the possible side effects of taking progesterone? While rarely dangerous, some possible side effects include depression, dizziness, headaches, backaches, insomnia, fluid retention, and enlargement of the liver or prostate.

What does progesterone do to a woman’s body?

Progesterone plays many crucial roles in a woman’s body but is often misunderstood. It acts as an essential hormone, regulating many processes that are vital in the female body and ensuring that a woman has a normal menstrual cycle.

Progesterone also helps regulate pregnancy, thickens the cervix after conception, thickens the breast, and increases the production of milk. In addition, Progesterone also regulates the levels of sex hormones such as estrogen and testosterone so that men don’t have to use synthetic steroids to achieve an erection.

Why is progesterone taken at night?

The use of oral contraceptives has been proven to prevent ovulation, reduce breast cancers and reduce abdominal fat. However, one thing that hasn’t received as much attention as any of those benefits is the effect it has on a woman’s night-time blood flow.

It is well known that estrogen is released into the bloodstream at certain times of the month through the sebaceous glands. What researchers have discovered is that this hormone can actually travel through the blood vessels during the night hours in some women, and this can have very dangerous consequences for a woman.

Now That You Know

If you have heard of progesterone before reading this article, you may have thought it was a ‘wonder drug.’ 

One of which had little to no side effects. Now that you have read this article, you have more of an understanding of progesterone side effects and know that this is not true. 

Of course, if you need to undergo HRT, you should always ask your doctor if taking Prometrium would be beneficial to you – in other words, would the benefits you would feel from taking medicine justify any side effects you may feel from it?


The possible side effects of using progesterone cream are numerous. This particular hormone may be useful to women experiencing symptoms of menopause such as hot flashes and night sweats but it is important to remember that progesterone may not be safe if used by itself and must be used in conjunction with some other hormones.

Some of the conditions where it may have undesirable effects include heart disease, osteoporosis, liver disease, uterine cancer, thrombosis, benign prostatic hyperplasia, certain types of cancers, rheumatoid arthritis, and Alzheimer’s disease.

It should be noted that this is a list compiled from the estrogen hormone and progesterone and therefore may not be inclusive of other possible interactions.

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