How Long Does Hydrocodone Stay In Your Urine? [2022] Updated

(Hydrocodone usually lasts for up to four days in your urine from the last intake of this tablet. However, there are certainly other factors that also determine its presence in urine)

The best way to get quick relief from severe pain is to rely on some pain relief medications.

If you are experiencing tremendous pain and you cannot be treated with other medicines, hydrocodone could be the best option to consider.

How Long Does Hydrocodone Stay In Your Urine

What is hydrocodone?

Derived from codeine, it comes from the poppy seeds rasin and is a natural alkaloid. It helps block the feeling of pain by activating the mu opiate receptors and binding them together. Hydrocodone is used in treating several types of pain, including surgery, arthritis, and cancer pain. It is an opioid drug that is used for people who cannot be treated with other medications.

Following are some of the brand names of hydrocodones which include ibuprofen or acetaminophen:

Hysteria ER and Zohydro are the extended-release formulations of hydrocodone. These are difficult to dissolve, crush, or break to avoid abuse.

With its high potential for addiction and abuse, it comes with warnings. It is classified as a federally controlled substance (C-II)

When Do You Start Feeling The Effects Of Hydrocodone?

Hydrocone is taken orally and passé through the digestive system to begin its effect. Typically within an hour, you will start feeling its effects. A 10-mg oral dose of hydrocodone shows the results in 1.3 years of its ingestion. If you are taking hydrocodone often, you will gradually develop tolerance to it over time.

You will gradually take longer to derive relief from the drug or may not feel the relief as secure as the other person who does not take hydrocodone often. It is advised not to take a high dosage of hydrocodone without consulting your doctor.

How Long Does Hydrocodone Stay In Your Urine?

The effect of hydrocodone starts diminishing within 5-6 hours. However, the traces of the medication in the saliva, urine, blood, and hair remains for longer. So, hydrocodone gets clear as follows:

  • This is from saliva, it takes 12 hours to 36 hours after the last dose if ingested
  • It is from urine, it takes four days after the previous dose is ingested
  • That is from hair, it takes 90 days after the previous dose is ingested

Even if the hydrocodone is not entirely clear off from your body, the ‘pain relief ‘effect of hydrocodone starts diminishing. Hence, the doctor recommends taking a tablet of hydrocodone after six to eight hours from the last dose taken if you are experiencing continuous pain. As the effect of extended-release medications lasts longer, these are recommended to take after 12 hours of the last treatment taken.

What Are The Factors Which Extend The Effects of Hydrocodone On Our Body?

There are several factors that influence the effects of hydrocodone in our body as follows:

  • Liver function
  • Weight
  • Metabolism
  • Body fat content
  • If opioids are taken along
  • Condition of other medications
  • Alcohol
  • Dosage
  • Other medications

The duration for which you are taking hydrocodone

The synergistic effects of alcohol, together with hydrocodone, suggest avoiding the intake of alcohol along with hydrocodone. It also takes more time than usual to clear off your body, if you ingested a hydrocodone tablet while having a drink. There is also a fair possibility of fatal overdosage by taking this medication along with the juice.

Cytochrome P450 3A (CYP3A) is the pathway through which the hydrocodone clears off from your body. While taking hydrocodone, the following should be avoided to be brought together to prevent any severe respiratory depression:

  • Azole antifungal agents
  • Protease inhibitor
  • Macrolide antibiotics

Some of the medications which can adversely react with hydrocodone are:

  • tricyclic antidepressants
  • narcotics
  • antihistamines
  • antidepressants are known as MAO inhibitors
  • anti-anxiety agents (like Xanax)

What are the various health issues at the time of withdrawing hydrocodone?

Some of the severe health withdrawal symptoms of hydrocodone are as follows:

  • Chills
  • Restlessness
  • Irritability
  • Sweating
  • Fast heartbeat
  • Joint pain
  • Fast breathing
  • Inability to sleep

Instead of quitting the medication in one go, it is recommended to reduce the dosage gradually and then stop taking the drug. After every two to five days, the effect of hydrocodone diminishes.

People Also Ask (FAQs)

How long does it take for tramadol to get out of your system? To exit your body completely, tramadol takes one and a half-day. It can be detected within 2 hours of consumption and up to 40 hours after eating in urine, saliva, hair, and blood.

How Much is Hydrocodone Too Much?

The presence of acetaminophen can be dangerous to health if taken being the prescribed levels. 750 mg of acetaminophen is present in one tablet of hydrocodone. The excessive intake of acetaminophen leads to liver damage.

How Would I Know That I Have Taken The Overdose of Hydrocodone?

If you experience any or some of the issues after ingesting hydrocodone, then it indicates that you have taken overdo of hydrocodone:

  • Abdominal distention
  • Bloating
  • Vomiting
  • Nausea
  • constipation

Is a Norco Stronger Than Vicodin?

Both of them are used to attack the pain in your body in multiple ways. Acetaminophen and opioids are the standard components available in both of them.

What Are The Common Side Effects of Taking Hydrocodone?

Vomiting, dry mouth, nausea, and constipation are some of the common side effects which one may experience while taking hydrocodone. People with asthma or respiratory issues should seek the opinion of a doctor before starting hydrocodone, as it may also cause a slow down of breath.


Typically within four to six hours, the pain relief effect of hydrocodone starts diminishing. For 1.5 days, it is easily detected in saliva, and it lasts for 90 days in urine from the last dose taken. Several other factors determine the extent of influence. Avoid taking a more significant amount of hydrocodone or continuously unless prescribed by the doctor.

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6 thoughts on “How Long Does Hydrocodone Stay In Your Urine? [2022] Updated”

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