Doxepin side effects, Use, Interactions 2021

If you are struggling with anxiety and depression, Doxepin is a medication that is generally prescribed to deal with such issues.

Doxepin side effects

By relieving the tension and stress, Doxepin helps you with sound sleep by promoting the feeling of well-being.

It is a tricyclic antidepressant that is responsible for balancing the natural chemicals of your brain to improve your mood.

What is Doxepin?

It is a prescription drug that is available as a topical cream, oral tablet, oral solution, and oral capsule. The oral pills are available in the generic version only.

Like other antidepressant medications, Doxepin is not free from side effects. If you are on Doxepin, these are some of the side effects which you should know:

Side Effects of Doxepin:

  • Dry mouth
  • Constipation
  • Dizziness
  • Drowsiness
  • Urination troubles
  • Blurred vision
  • Vomiting or nausea
  • Weight gain
  • Change in taste buds
  • Upset stomach

Besides the side-effects above, there are some severe side effects that are covered under medical emergency as follows:

  • Urinary retention such as
  • Pain during urination
  • Not able to empty your bladder completely
  • Bloating or pain in your lower belly
  • Suicidal thoughts and worsening depression such as
  • Panic attacks
  • Sleeping troubles
  • Attempt to commit suicide
  • Worsened irritability
  • Extreme increase in talking or activity
  • Feeling restless and agitated
  • Unusual behavioral and mood swings

(Disclaimer: We are striving to deliver the best possible information. However, the side effects of way medication vary from person to person. So far, we have covered the possible side effects to the best of our knowledge. But this article is not a substitute for medical advice.

One should consult a medical practitioner to understand his/her underlying condition and any possible side effect associated with it. )

It is essential to get up very slowly from a sitting or lying position to avoid any fall due to drowsiness. Increased intake of dietary fiber helps in relieving constipation. Drink plenty of water and chew sugarless gums to prevent dry mouth symptoms.

The benefits of the medications are undoubtedly higher than the associated side effects.

It is possible not to have any of the side effects, as mentioned earlier.

Precautions which one should take to avoid side-effects

As it is tricyclic antidepressants, you must not be allergic to such medication. Take note of all the ingredients and ensure that you do not have any allergic reactions. Doxepin may also affect your heart rhythm, which is rare but possible.

You should disclose to your pharmacist, If you are experiencing one or more issues as follows:

  • Overactive Thyroid
  • Family or personal history of any mental disorder
  • Breathing problems
  • Recent heart attack
  • Liver problems
  • Bleeding problems
  • Urination issues
  • History of glaucoma

How do Doxepin works?

Doxepin possibly blocks the norepinephrine reabsorption capacity of your brain, which is responsible for fluctuating your mood. As the level of norepinephrine increases in your body, it improves your mood and keeps you happy.

What are the possible interactions of Doxepin?

The interactions can alter the working of medications and also increases the risk of side effects. It is essential to consult your doctor to start, change, or stop the dosage of Doxepin. Some of the possible interaction which Doxepin can cause with the following medications:

Thyroid Supplements

Central acting drugs for the treatment of High blood pressure

  • Anticholinergic Drugs
  • Arbutamie
  • MAO inhibitors (it is a fatal interaction)
  • Antifungal drugs
  • Kidney disease drugs
  • Heart rhythm drugs
  • Diabetes drug
  • Stomach infection drugs

It is essential to manage all your medications to avoid any possible interactions. It is crucial to reveal all the medicines, herbs, or vitamins that you are taking before starting Doxepin.

Frequently Asked Questions

Here are some frequently asked questions which are often discussed for Doxepin as follows:

Can Doxepin get you high?

As Doxepin is an antidepressant pill, it can evoke the thought of suicide. Notably, during the first few months of treatment, you can experience higher side effects.

Is Doxepin a sleeping pill?

This antidepressant pill helps you to sleep longer and sound. Especially if you frequently awake at midnight, it helps you to sleep better without frequently waking up.

What is Doxepin prescribed for?

Doxepin is a tricyclic antidepressant that is generally used to treat depression and anxiety symptoms. It has an impact on brain chemicals, which leads to imbalance. It is mainly prescribed for manic-depression, alcoholism, and other psychiatric conditions.

What are the ingredients of Doxepin?

Glycerin, Peppermint flavor, water, methylparaben, propylparaben, and glycerin are some of the ingredients of Doxepin.


Doxepin is primarily available in three forms, out of which the oral capsule is mainly used to treat depression and anxiety. FDA has given it a black box warning, which highlights the possible dangerous levels. This medication to doctors and patients. During the first few months of treatment, the risk of suicidal thoughts and other side effects is quite high.

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